Glyphosate and Neurodegenerative Disease
Glyphosate is the most common herbicide globally and has been correlated with neurodegeneration in past in-vitro trials. In a recent animal study, the authors showed just how toxic this chemical is to brain function and detailed how Glyphosate crossed the blood brain barrier and activated a pro-inflammatory molecule; TNF-alpha. The study also found how Glyphosate increased soluble amyloid beta and disrupted the function of cortical neurons, which lead to toxicity. See below from the paper: (R)

"RNAseq revealed over 200 differentially expressed genes in a dose-dependent manner and cell-type-specific deconvolution analysis showed enrichment of key biological processes in oligodendrocytes including myelination, axon ensheathment, glial cell development, and oligodendrocyte development.
Aberrant TNF-alpha signaling has been implicated in numerous pathological conditions including cancer, rheumatoid arthritis, psoriasis, multiple sclerosis, as well as immune, inflammatory, and neurodegenerative diseases like Alzheimer’s disease (AD). In the healthy brain, TNF-alpha expression is low in adulthood while in contrast, adult neurodegenerative diseased brains show very high levels of TNF-alpha. Neuroinflammation plays a central role in AD pathogenesis and TNF-alpha specifically has been strongly implicated in the progression of AD.
Commentary:
This lends importance since neuroinflammation not only plays a role in neurodegenerative conditions, but also psychological symptoms and conditions as well. We've seen numerous papers link low-grade inflammation to depression for example. (R) It seems that inflammation may be driven from the periphery, and have the ability to disrupt neurotransmitters and neurocircuitry leading to depression. Those with diagnosed depression demonstrate markers consistent with inflammation including Interleukin-6, acute phase proteins such as c-reactive protein (CRP) and high levels of chemokines and adhesion molecules. In a different perspective, administration of endotoxins and inflammatory mediators cause depression in non-depressed individuals. (R) Inflammation has also been implicated in the reasons why some people fail anti-depressant therapy, which I consistently see in practice. So, in summary, the brain-immune cross-talk is real and chemicals such as glyphosate that induce neuroinflammation must be controlled among other variables that cause inflammation. And, inflammation seems to be the driving factor with depression and other psychiatric illnesses so consideration of an anti-inflammatory diet and nutrients may help immensely.
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